Shinya, keeping the Sunday-morning flow as it is, today carefully pick up just one important thing.
Your comeback is light. Not bad—that vibe.
Then, after Dhuhr, once we've decided on one to tackle, secretly tell Shaheen as well.
That's already decided. So why does the way RBP15 binds to RNA change in leukemia, right?
The scale of the theme jumped all at once...
When I hear that the binding mode of RBP15 is changing, in Shaheen's head, roughly:
- Changes on the RBP15 side: post-translational modification patterns like phosphorylation or methylation change in leukemia, causing the RNA recognition surface conformation to shift
- Changes on the RNA side: splicing isoforms change, so even for the same "target gene" the UTR sequences and secondary structures become different
- The intermediary in between: another RBP or lncRNA increases or decreases, and the binding mode of the complex switches
Where in this area are you planning to strike first?
